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For customers experiencing a 421 error on their websites within Plesk on their servers, please note that Plesk is a third-party software. For assistance, we recommend visiting the official Plesk online help website, which should provide the necessary solutions and troubleshooting guidance.
Plesk have released an article with instructions on how to solve the issue:
https://support.plesk.com/hc/en-us/articles/33500191748887-Websites-hosted-in-Plesk-are-not-accessible-after-a-recent-Apache-update-421-Misdirected-Request
With IsDown, you can monitor all your critical services' official status pages from one centralized dashboard and receive instant alerts the moment an outage is detected. Say goodbye to constantly checking multiple sites for updates and stay ahead of outages with IsDown.
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